תקציר
Dose-Intensive Chemotherapy with Continuous Infusion 5-Fluorouracil
T. Tichler, E. Ghodsizade, A. Katz, P. Rath, R. Berger, H. Brenner
Sheba Medical Center, Tel Hashomer, and Beilinson Medical Center, Petah Tikvah
54 patients with advanced malignancy refractory to chemotherapy were studied to evaluate efficacy and toxicity of continuous infusion of 5-fluorouracil (5FU) given for 3 weeks. We report results of the first 156 courses given in combination with other drugs.
19 (37%) of the 54 responded, including 3 (6%) with complete response. Toxicity was acceptable, with mucositis in 13 (26%) and 3 (6%) with grade II-III toxicity. Results and toxicity profile were compatible with further disease-oriented studies using this dose-intensive program.