CASE COMMUNICATIONS
IMAJ | volume 25
Journal 12, December 2023
pages: 828-829
A Severe Acute Kidney Injury Following Zoledronic Acid Therapy Leading to Chronic Hemodialysis Treatment: A Case Report
1 Department of Internal Medicine E, Meir Medical Center, Kfar Saba, Israel
2 Department of Nephrology, Meir Medical Center, Kfar Saba, Israel
3 Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Summary
Higher potency bisphosphonates, typically intravenous formulations, are given at lower doses for postmenopausal women. The treatment has improved compliance compared to daily oral therapy. Since bisphosphonates are exclusively excreted via the kidneys, intravenous formulation has been associated with deterioration of renal function, specifically in the setting of preexisting renal disease or concomitant use of nephrotoxic agents [1].