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    עמוד בית
    Mon, 14.04.25

    CASE COMMUNICATIONS

    IMAJ | volume 27

    Journal 4, April 2025
    pages: 255-257

    Minocycline-induced Polyarteritis Nodosa Manifesting as Tenosynovitis, Edema, and Rash: A Case Report

    1 Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 2 Internal Medicine Consultations and Internal Medicine Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 3 Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Israel 4 Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel

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    Summary

    Minocycline is a tetracycline antibiotic prescribed to treat various infections, acne vulgaris, and rosacea. In addition to its antibiotic activity, it possesses anti-inflammatory properties, including reducing the production of proinflammatory cytokines, suppressing neutrophil chemotaxis, activating superoxide dismutase, and inhibiting phagocytosis. Among its side effects are hypersensitivity syndrome reactions, drug-induced lupus, and polyarteritis nodosa (PAN) [1].

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