IMAJ | volume 27
Journal 2, February 2025
pages: 122-123
1 Department of Internal Medicine E, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel
2 Infectious Diseases Unit, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel
3 Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Summary
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder of immune dysregulation characterized by an inadequate attenuation of the cytotoxic and innate immune system resulting in uncontrolled inflammation in multiple organ systems. Predominant clinical findings include fever, cytopenia, and hepatosplenomegaly [1].
Infectious diseases are a well-documented trigger of HLH, with viral infection being the most common cause. Less commonly, HLH has also been reported in the setting of bacterial infections, with rare cases described secondary to rickettsial diseases [1]. In this report, we present a case of HLH in the setting of bacterial infection with Rickettsia typhi, murine typhus.