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    עמוד בית
    Tue, 18.03.25

    CASE COMMUNICATIONS

    IMAJ | volume 27

    Journal 2, February 2025
    pages: 120-121

    From Fat to Muscle

    1 Department of Medicine C, Wolfson Medical Center, Holon, Israel 2 Department of Neurology, Wolfson Medical Center, Holon, Israel 3 Intensive Care Unit, Wolfson Medical Center, Holon, Israel 4 Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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    Summary

    Myositis is described as any disease-causing inflammation in muscles. Muscle weakness is the most common symptom. Etiology includes infection, injury, medication side effects, and autoimmune conditions. The treatment varies according to the cause [1]. Statin induced necrotizing autoimmune myopathy (SINAM) is an exceptionally rare yet devastating complication of statin therapy that can occur at any time after initiation. The condition is also known as anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody (anti-HMGCR antibody) myopathy. SINAM should be considered in patients who develop proximal muscle weakness and marked elevated creatine phosphokinase (CPK) while taking statin therapy [2]. We report on a patient who presented with excessive fatigue, generalized muscle pain, and weakness without dysphagia.

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