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    עמוד בית
    Fri, 11.04.25

    Original Articles

    IMAJ | volume 12

    Journal 1, January 2010
    pages: 39-41

    Respiratory Syncytial Virus-Positive Bronchiolitis in Hospitalized Infants is Associated with Thrombocytosis

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      Summary

      Background: Secondary thrombocytosis is associated with a variety of clinical conditions, one of which is lower respiratory tract infection. However, reports on thrombocytosis induced by viral infections are scarce.

      Objectives: To assess the rate of thrombocytosis (platelet count > 500 x 109/L) in hospitalized infants with bronchiolitis and to investigate its potential role as an early marker of respiratory syncytial virus infection.

      Methods: Clinical data on 469 infants aged ≤ 4 months who were hospitalized for bronchiolitis were collected prospectively and compared between RSV[1]-positive and RSV-negative infants.

      Results: The rate of thrombocytosis was significantly higher in RSV-positive than RSV-negative infants (41.3% vs. 29.2%, P = 0.031). The odds ratio of an infant with bronchiolitis and thrombocytosis to have a positive RSV infection compared to an infant with bronchiolitis and a normal platelet count was 1.7 (P = 0.023, 95% confidence interval 1.07–2.72). There was no significant difference in mean platelet count between the two groups.

      Conclusions: RSV-positive bronchiolitis in hospitalized young infants is associated with thrombocytosis.


      [1] RSV = respiratory syncytial virus

       

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