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    עמוד בית
    Sat, 12.04.25

    Original Articles

    IMAJ | volume 16

    Journal 2, February 2014
    pages: 78-82

    Atypical Fractures of the Femur Related to Prolonged Treatment with Bisphosphonates for Osteoporosis

      Full article (PDF)

      Summary

      Background: Bisphosphonates reduce the overall risk of fractures among patients with osteoporosis, and this beneficial effect is long-lasting. However, since bisphosphonates inhibit bone remodeling, they may enhance the formation and propagation of micro-cracks over time and patients may therefore be prone to atypical fatigue fractures, mainly in the subtrochanteric region and femoral shaft.

      Objectives: To present two cases of subtrochanteric fractures related to bisphosphonate treatment and review of the current literature.

      Conclusions: Despite the overall beneficial effect of bisphosphonates, further research is required to prevent this significant complication. 

      Full article (PDF)
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