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    עמוד בית
    Tue, 01.04.25

    Reviews

    IMAJ | volume

    Journal 5, May 2001
    pages: 360-363

    Viral dynamics in hepatitis C

      Full article (PDF)

      Summary

      The hepatitis C virus is an enveloped positive-sense single-stranded RNA virus, which has been classified into 6 major genotypes and over 100 subtypes. HCV replicates mainly in the hepatocyte. Recently, infectious HCV cDNA clones have been generated. Despite evidence that innate and adaptative humoral and cellular immune responses are activated as part of an antiviral defense, HCV has a remarkable ability to establish persistent infection. The analysis of viral kinetics using mathematical modeling shows a relative steady state without treatment, while an immediate biphasic HCV decline occurs in blood during successful treatment, the latter being predictive of clearance of HCV by the end of treatment.

      Full article (PDF)
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