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    עמוד בית
    Thu, 03.04.25

    CASE COMMUNICATION

    IMAJ | volume 25

    Journal 5, May 2023
    pages: 377-378

    A Fatal Case of Ruxolitinib Discontinuation Syndrome Preceded by Hypercalcemia

    1 Department of Internal Medicine C, Shamir Medical Center (Assaf Harofeh), Zerifin, Israel 2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Full article (PDF)

    Summary

    Ruxolitinib is an inhibitor of the cytosolic tyrosine kinase Janus kinase (JAK) family of proteins (JAK1/2), which is widely used to treat various myeloid neoplasms that are characterized by constant activation of the JAK-STAT signaling pathway.

    Many side effects are associated with ruxolitinib, including anemia, thrombocytopenia, increased rate of infections (especially herpes zoster), and mild hypercalcemia noted in 15.4% of patients [1]. The possible mechanism causing hypercalcemia may involve altered bone and mineral metabolism with secondary hyperparathyroidism, as described for other kinase inhibitors [2].

    Full article (PDF)
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