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    עמוד בית
    Thu, 03.04.25

    CASE COMMUNICATION

    IMAJ | volume 25

    Journal 5, May 2023
    pages: 369-371

    Localized Pulmonary Calcinosis: A Unique Presentation of a Rare Disease

    1 Department of Internal Medicine A, Samson Assuta Ashdod University Hospital, Ashdod, Israel 2 Department of Pathology, Samson Assuta Ashdod University Hospital, Ashdod, Israel 3 Department of Radiology, Samson Assuta Ashdod University Hospital, Ashdod, Israel 4 Department of Pulmonology, Samson Assuta Ashdod University Hospital, Ashdod, Israel 5 Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel

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    Summary

    Metastatic pulmonary calcinosis (MPC) is characterized by deposits of calcium in normal pulmonary parenchyma. Diffuse pulmonary calcinosis commonly occurs in hypercalcemia and/or hyperphosphatemia and is more commonly related to renal failure than primary hyperparathyroidism, skeletal metastases, or multiple myeloma [1]. Calcium depositions favor alkaline tissue and are thus more common in the upper lobes of the lung, which have a higher ventilation to perfusion ratio and a low capillary pCO2, resulting in an alkaline pH [2]. Therefore, the most common radiographic manifestation consists of poorly defined nodular opacities bilaterally in the upper lung zones [3].

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