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    עמוד בית
    Thu, 03.04.25

    Original Articles

    IMAJ | volume 21

    Journal 7, July 2019
    pages: 444-448

    Proteome-Wide Epstein-BarrVirus Analysis of Peptide Sharing with Human Systemic Lupus Erythematosus Autoantigens

    Full article (PDF)

    Summary

    Background:

    Although cross-reactions between Epstein-Barr virus (EBV) and human systemic lupus erythematosus (SLE) autoantigens occur, a complete analysis of the potential EBV peptide cross-reactome has not been performed.

    Objectives:

    To analyze the whole EBV proteome searching for peptides common to SLE-related proteins and endowed with an immunological potential.

    Methods

    : Fifty-one SLE-related proteins were analyzed for hexapeptide sharing with EBV proteome using publicly available databases.

    Results

    : An extremely high number of hexapeptides are shared between 34 human SLE autoantigens and EBV proteins. The peptide sharing mostly occurs with complement components C4 and Interleukin-10 (IL-10).

    Conclusion

    : This study thoroughly describes the EBV vs. SLE autoantigens peptide overlap and powerfully supports cross-reactivity as a major mechanism in EBV-associated SLE etiopathogenesis.

    Full article (PDF)
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