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    עמוד בית
    Thu, 03.04.25

    Original Articles

    IMAJ | volume 17

    Journal 9, September 2015
    pages: 538-540

    Left Cardiac Sympathetic Denervation in Patients with CASQ2-Associated Catecholaminergic Polymorphic Ventricular Tachycardia

      Full article (PDF)

      Summary

      Background:

      Left cardiac sympathetic denervation (LCSD) was reported to be effective in patients with intractable ryanodine receptor mutation-associated catecholaminergic polymorphic ventricular tachycardia (CPVT). 

      Objectives:

      To report our experience with LCSD in calsequestrin (CASQ2) mutation-associated CPVT. 

      Methods:

      LCSD was performed in three patients with CASQ2 mutation-associated CPVT with symptoms and exercise-induced ventricular arrhythmia despite high dose beta-blocker. 

      Results:

      None of them experienced symptoms or exercise-induced ventricular arrhythmia after LCSD. However, all had recurrence of symptoms and/or exercise-induced ventricular arrhythmia after 6 months (6–18 months).

      Conclusions:

      LCSD conferred short-term suppression but less than optimal long-term suppression of exercise-induced ventricular arrhythmia among CASQ2-associated CPVT patients.

       

      Full article (PDF)
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