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    עמוד בית
    Thu, 03.04.25

    Original Articles

    IMAJ | volume

    Journal 10, October 1999
    pages: 95-97

    Phenytion Induced Severe Cutaneous Drug Reactions: Suspected Interactions with Corticosteroids and H2 Blockers

      Full article (PDF)

      Summary

       Background: Cutaneous drug reactions are attributed usually to one culprit drug, however, some CDRs1 may be associated with drug interactions.

      Objectives: To present a case series of foyr patients with phenytion-induced severe CDRs, including toxic epidermal necrolysis (2 patients), exanthematous eruption (1 patient) and hypersensitivity syndrome (1 patient). In all patients the reactions appeared following the combined intake of phenytion, corticosteroids and H2 blockers.

      Conclusions: Our case series may imply the role of drug interactions between phenytion, corticosteroids and H2 blockers in the induction of severe CDRs.

      Full article (PDF)
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